- Title
- Resting plasma and salivary IL-6 concentrations are not correlated in distance runners
- Creator
- Cox, Amanda J.; Pyne, David B.; Gleeson, Maree; Callister, Robin
- Relation
- European Journal of Applied Physiology Vol. 103, Issue 4, p. 477-479
- Publisher Link
- http://dx.doi.org/10.1007/s00421-008-0722-x
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2008
- Description
- Measurement of IL-6 has been widely undertaken to examine inflammatory and immune responses to exercise. Use of salivary IL-6 offers an alternative to the invasive collection procedures required for IL-6 measurement in plasma samples. Rarely, however, has the degree of association between plasma and salivary IL-6 been reported. The aim of the current study was to investigate the relationship between resting salivary and plasma IL-6 concentrations in 45 trained distance runners (36 males, 9 females; age: 35.1 ± 8.0 y, mean ± SD). Plasma and saliva samples were collected from athletes under resting conditions. Plasma IL-6 concentrations were determined using a Bioplex suspension array system and commercially available reagents. Salivary IL-6 concentrations were determined using a commercially available high-sensitivity ELISA kit. At rest, the mean (± SD) plasma IL-6 concentration was 3.43 ± 3.75 pg mL⁻¹ compared to a mean salivary IL-6 concentration of 1.80 ± 4.25 pg mL⁻¹. IL-6 concentrations in plasma and saliva samples were not correlated (r= -0.031, p = 0.85). At rest, salivary IL-6 concentrations do not reflect plasma IL-6 concentrations. The potential for salivary IL-6 to act as a surrogate marker for plasma IL-6 responses when examining inflammatory and immune responses to exercise, therefore, appears unlikely.
- Subject
- athletes; cytokines; exercise; immunity
- Identifier
- http://hdl.handle.net/1959.13/43402
- Identifier
- uon:5515
- Identifier
- ISSN:1439-6319
- Language
- eng
- Reviewed
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